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KMID : 0364020170500060471
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Korean Journal of Thoracic and Cardiovascular Surgery
2017 Volume.50 No. 6 p.471 ~ p.473
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Carney Complex: Eleven Open Heart Operations in a Single Family
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Han Sung-Joon
Han Woo-Sik
Kang Min-Woong
Yu Jae-Hyeon
Kang Shin-Kwang
Na Myung-Hoon
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Abstract
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Herein, we report on a family with Carney complex. Four members of the family underwent a total of 11 open heart operations as well as 9 other operations to treat extrathoracic masses. All the family members met at least 2 major clinical criteria and 1 supplemental criterion. We analyzed their genomic loci, including the protein kinase A regulatory subunit 1 gene. The results revealed no specific mutations, except for a common single nucleotide polymorphism. This case series of Carney complex emphasizes the importance of close longitudinal follow-up because of the high rate of tumor recurrence irrespective of the site. Clinicians should not overlook the specific features of familial myxoma.
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KEYWORD
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Carney complex, Myxoma, Familial myxoma
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